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PD 404182
CAS No. 72596-74-8
PD 404182 ( PD404182;PD-404182 )
Catalog No. M15780 CAS No. 72596-74-8
PD 404182 (PD404182, PD-404182) is a heterocyclic iminobenzothiazine derivative with antimicrobial and anti-inflammatory properties, a potent inhibitor of human DDAH1 activity (IC50=9 uM) and elevates cellular ADMA levels.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePD 404182
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NoteResearch use only, not for human use.
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Brief DescriptionPD 404182 (PD404182, PD-404182) is a heterocyclic iminobenzothiazine derivative with antimicrobial and anti-inflammatory properties, a potent inhibitor of human DDAH1 activity (IC50=9 uM) and elevates cellular ADMA levels.
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DescriptionPD 404182 (PD404182, PD-404182) is a heterocyclic iminobenzothiazine derivative with antimicrobial and anti-inflammatory properties, a potent inhibitor of human DDAH1 activity (IC50=9 uM) and elevates cellular ADMA levels; significantly increases intracellular levels of ADMA and reduces LPS-induced NO production in cultured primary human vascular endothelial cells (ECs), abrogates the formation of tube-like structures by ECs in in vitro angiogenesis assay; also shows anti-HIV and anti-HSV activites.Bacterial Infection Discontinued
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SynonymsPD404182;PD-404182
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research AreaInfection
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IndicationBacterial Infection
Chemical Information
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CAS Number72596-74-8
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Formula Weight217.29
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Molecular FormulaC11H11N3S
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Purity>98% (HPLC)
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Solubility——
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SMILESN=C1SC2=CC=CC=C2C3=NCCCN13
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Chemical Name6H-6-imino-(2,3,4,5-tetrahydropyrimido)[1,2-c]-[1,3]benzothiazine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ghebremariam YT, et al. J Pharmacol Exp Ther. 2014 Jan;348(1):69-76.
2. Mizuhara T, et al. Bioorg Med Chem. 2013 Apr 1;21(7):2079-87.
3. Ghebremariam YT, et al. J Pharmacol Exp Ther. 2014 Jan;348(1):69-76.
4. Chamoun-Emanuelli AM, et al. Antimicrob Agents Chemother. 2014;58(2):687-97.
2. Mizuhara T, et al. Bioorg Med Chem. 2013 Apr 1;21(7):2079-87.
3. Ghebremariam YT, et al. J Pharmacol Exp Ther. 2014 Jan;348(1):69-76.
4. Chamoun-Emanuelli AM, et al. Antimicrob Agents Chemother. 2014;58(2):687-97.
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