Cart
sales@molnova.com
Home - Products - Microbiology/Virology - HIV - PD 404182

PD 404182

CAS No. 72596-74-8

PD 404182 ( PD404182;PD-404182 )

Catalog No. M15780 CAS No. 72596-74-8

PD 404182 (PD404182, PD-404182) is a heterocyclic iminobenzothiazine derivative with antimicrobial and anti-inflammatory properties, a potent inhibitor of human DDAH1 activity (IC50=9 uM) and elevates cellular ADMA levels.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PD 404182
  • Note
    Research use only, not for human use.
  • Brief Description
    PD 404182 (PD404182, PD-404182) is a heterocyclic iminobenzothiazine derivative with antimicrobial and anti-inflammatory properties, a potent inhibitor of human DDAH1 activity (IC50=9 uM) and elevates cellular ADMA levels.
  • Description
    PD 404182 (PD404182, PD-404182) is a heterocyclic iminobenzothiazine derivative with antimicrobial and anti-inflammatory properties, a potent inhibitor of human DDAH1 activity (IC50=9 uM) and elevates cellular ADMA levels; significantly increases intracellular levels of ADMA and reduces LPS-induced NO production in cultured primary human vascular endothelial cells (ECs), abrogates the formation of tube-like structures by ECs in in vitro angiogenesis assay; also shows anti-HIV and anti-HSV activites.Bacterial Infection Discontinued
  • Synonyms
    PD404182;PD-404182
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    Infection
  • Indication
    Bacterial Infection

Chemical Information

  • CAS Number
    72596-74-8
  • Formula Weight
    217.29
  • Molecular Formula
    C11H11N3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N=C1SC2=CC=CC=C2C3=NCCCN13
  • Chemical Name
    6H-6-imino-(2,3,4,5-tetrahydropyrimido)[1,2-c]-[1,3]benzothiazine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ghebremariam YT, et al. J Pharmacol Exp Ther. 2014 Jan;348(1):69-76.
2. Mizuhara T, et al. Bioorg Med Chem. 2013 Apr 1;21(7):2079-87.
3. Ghebremariam YT, et al. J Pharmacol Exp Ther. 2014 Jan;348(1):69-76.
4. Chamoun-Emanuelli AM, et al. Antimicrob Agents Chemother. 2014;58(2):687-97.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Helichrysetin

    Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29.Searching for anti-HIV-1 protease (PR) inhibitors of Thai medicinal plants led to the isolation of a new cyclohexenyl chalcone named panduratin C and chalcone derivatives (2-6) from the methanol extract of Boesenbergia pandurata rhizomes.

  • Delavirdine mesylate

    A potent HIV-1 reverse transcriptase inhibitor with IC50 of 0.26 uM for recombinant HIV-1 RT.

  • Isoxanthohumol

    Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV).

Sign In Join Free